RNA Details
Disease Name
Idiopathic Pulmonary Arterial Hypertension
Tissue
lung
RNA Symbol
SOD3
RNA ID
RNA Type
mRNA
Alteration Pattern
histone deacetylation
Species
homo sapiens
Detection Methods
qRT-PCR; SOD Activity etc.
Target
NA
Pathway
NA
PubMed ID
Title
Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension
Year
2016
Function
"Histone deacetylation, specifically via class I HDAC3, decreases SOD3 expression in PASMC and HDAC inhibitors may protect IPAH in part by increasing PASMC SOD3 expression."